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Abstract #2303

Two Anesthetics, Two Completely Different Connectivity Results

Erik B. Beall1, John T. Gale2, Ken E. Sakaie1, Mark J. Lowe1

1Imaging Institute, Cleveland Clinic, Cleveland, OH, United States; 2Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States

Studies of resting connectivity under anesthesia have shown modulation of connectivity patterns with a strong dependence on the choice of anesthetic. Propofol appears to have an increasing usage in human and animal anesthesia connectivity studies. However, it is possible propofol is a poor choice. Based on a failure to find reasonable connectivity patterns in a pilot BOLD scan under propofol, we acquired two long scan sessions (separated by several months) under two different anesthetics and found reasonable connectivity patterns under ketamine but a complete absence of connectivity patterns under propofol.