Complex and Widespread Network Modulations During Simple Tasks: Trial-By-Trial Spatio-Temporal Dynamics of Brain Function Revealed by Model-Free Analysis

Stephen D. Mayhew¹, Andrew P. Bagshaw¹

We use model-free analysis to characterise the spatio-temporal dynamics activity in multiple brain networks both preceding and during visual and pain stimulation paradigms. We find that stimulus modulations occur at multiple time-points, creating high degree of variability in the shape and polarity of trial-by-trial brain responses. The pre-stimulus BOLD signal amplitude in the DAN and DMN was found to predict the amplitude of the primary visual and pain stimulus-responses.