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Abstract #2450

Mono-Exponential T2-Analysis of a Two-Pool System Does Echo-Spacing Matter?

Hendrikus Joseph Alphons Crooijmans1, Oliver Bieri1

1Radiological Physics, University of Basel Hospital, Basel, Switzerland

It is generally well accepted that tissue exists of multiple relaxation components, such as for example the free water protons and myelin-bound water protons in brain tissue. However, the spin-echo based quantification of a single T2 on such tissues is commonly considered being the gold standard. Within such an approach, the echo-spacing is believed to be of influence on the obtained T2. By means of simulations, we have shown that the echo spacing in a spin-echo acquisition for T2-quantification does not matter when performing a mono-exponential analysis of a two-pool system.