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Abstract #2449

Single Breath-Hold 3D Radial Imaging for R2* and Fat Fraction Quantification in the Liver

Valentina Taviani1, Kevin M. Johnson1, Diego Hernando2, Scott B. Reeder1, 3

1Radiology, University of Wisconsin, Madison, WI, United States; 2Radiology, University of Wisconsin-Madison, Madison, WI, United States; 3Medical Physics, University of Wisconsin, Madison, WI, United States

In the presence of hepatic iron overload, quantification of R2* and fat fraction (FF) can be limited by the rapidly decaying signal. In this work, we propose a multi-echo 3D radial acquisition with angular undersampling and non-Cartesian parallel imaging reconstruction for hepatic R2* and FF quantification in a single breath hold. Phantom experiments and a preliminary evaluation in healthy volunteers and patients with hepatic iron overload are reported, including a comparison with a hybrid (in-plane radial, through-plane Cartesian) 3D sampling scheme and conventional 3D Cartesian sampling.