Abstract #2449

Single Breath-Hold 3D Radial Imaging for R2* and Fat Fraction Quantification in the Liver

Valentina Taviani¹, Kevin M. Johnson¹, Diego Hernando², Scott B. Reeder¹,³

¹Radiology, University of Wisconsin, Madison, WI, United States; ²Radiology, University of Wisconsin-Madison, Madison, WI, United States; ³Medical Physics, University of Wisconsin, Madison, WI, United States

In the presence of hepatic iron overload, quantification of R₂* and fat fraction (FF) can be limited by the rapidly decaying signal. In this work, we propose a multi-echo 3D radial acquisition with angular undersampling and non-Cartesian parallel imaging reconstruction for hepatic R₂* and FF quantification in a single breath hold. Phantom experiments and a preliminary evaluation in healthy volunteers and patients with hepatic iron overload are reported, including a comparison with a hybrid (in-plane radial, through-plane Cartesian) 3D sampling scheme and conventional 3D Cartesian sampling.