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Abstract #2492

Evaluation of Multiparametric QBOLD in White Matter: A Simulation Study

Julien Bouvier1, 2, Sebastien Castellani1, Clment S. Debacker1, 3, Nicolas Pannetier4, Irne Troprs, 15, Alexandre Krainik1, Emmanuel Luc Barbier1

1INSERM U836, Grenoble Institute of Neurosciences, Grenoble, France; 2Philips Healthcare, Suresnes, France; 3Bruker Biospin MRI, Ettlingen, Germany; 4University of California San Francisco, San Francisco, CA, United States; 5Plate-forme IRMaGe, UJF INSERM US17 CNRS UMS 3552, Grenoble, France

Quantitative estimates of the tissue blood oxygen saturation (StO2) may be obtained using a multiparametric quantification of the blood oxygen level dependent effect (multiparametric qBOLD). This method, based on a model of the MR signal, yielded promising experimental results on rodents. However, the first estimates of StO2 obtained in humans with this method matched those reported in the literature for gray matter only. To obtain reliable StO2 estimates in white matter, this study evaluates a solution to account for the bias on StO2 estimate induced by myelin, a paramagnetic substance, using a numerical simulation approach.