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Abstract #2517

31P and 1H NMR Investigation of Liquid Crystal Phase Temperature Dependence in Rehydrated Myelin

Henry H. Ong1, Michael J. Wilhelm2, Suzanne L. Wehrli3, Edward James Delikatny4, Felix W. Wehrli1

1Laboratory for Structural NMR Imaging, Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States; 2Department of Chemistry, Temple University, Philadelphia, PA, United States; 3NMR Core Facility, Children's Hospital of Philadelphia, Philadelphia, PA, United States; 4Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

Understanding MR properties of myelin would provide valuable insight into current MRI methods for myelin imaging. Myelin forms a lamellar liquid crystal lipid system whose phase behavior is influenced by temperature. In recent work the MR properties of rehydrated myelin extracts have been studied at room temperature, but whether the results apply to physiological temperature is not currently understood. Here, we studied the temperature dependence (10-50&[deg]C) of the liquid crystal phase of rehydrated bovine myelin extract with 31P and 1H NMR. The results are consistent with myelin lipids exhibiting a lamellar liquid crystal phase over this temperature range