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Abstract #2535

Specific Inhomogeneous MT Contrast in Mouse Brain White Matter

Guillaume Duhamel1, Olivier M. Girard1, Gopal Varma2, Patrick J. Cozzone1, Virginie Callot1, David C. Alsop2

1CRMBM / CNRS 7339, Aix-Marseille University, Marseille, France; 2Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States

Specific imaging able to provide quantification of myelin concentration would be a very valuable tool for clinical and preclinical studies of white matter pathologies. While several advanced MR techniques are used to assess myelin content (short T2 imaging, MWF, MT ), they all are affected by confounding factors which limit their specificity to myelin. A new MT approach specific to the inhomogenous component of the MT spectrum was applied on human at 3T and appeared to be selectively sensitive to tissue with myelin. Here, we investigated the specificity of this inhomogenous MT sequence in mouse brain at 11.75T