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Abstract #2547

The Non-Linearity of CEST and MT Signal Combination

Sheng-Min Huang1, Chih-Kuang Yeh1, Fu-Nien Wang1

1Department of Biomedical Engineering & Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan

The interference from magnetization transfer (MT) in chemical exchange saturation transfer (CEST) complicates the issue of quantitative measurement. In this study, we performed both numerical simulation and phantom experiment to identify if linear combining assumption of CEST and MT signal is appropriate. Both our results showed that the mix signal of CEST and MT were overestimated approximately 25% by linear model, which indicates that linear combination fails to describe the relations between CEST and MT signal. Comprehensive study of CEST and MT relationship is needed for reducing the asymmetric MT effect.