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Abstract #2549

Simplified RF Spillover-Corrected Omega Plot for Simultaneous Determination of Labile Proton Ratio and Exchange Rate

Phillip Zhe Sun1, Gang Xiao2, Renhua Wu3

1Radiology, Martinos Center for Biomedical Imaging, Charlestown, MA, United States; 2Department of Math and Information Technology, Hanshan Normal University, Chaozhou, Guangdong, China; 3Department of Medical Imaging, Medical College of Shantou University, Chaozhou, Guangdong, China

Whereas CEST-weighted MRI has provided tremendous insights, it is important to develop quantitative CEST (qCEST) analysis to characterize the underlying CEST system. We here postulated that the concomitant RF spillover effects can be reasonably estimated for simplified qCEST analysis. Specifically, both the labile proton ratio and exchange rate can be determined from RF spillover factor corrected modified omega plot. The proposed qCEST analysis was validated both numerically and experimentally. In ry, our study established a simplified qCEST analysis algorithm, which remains promising to aid the ongoing development of qCEST MRI.