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Abstract #2553

Differentiation and Quantification of Exchanging Protons in Different Pool Resonating at the Same Frequency in CEST

Olivier E. Mougin1, Penelope A. Gowland2

1SPMMRC, School of Physics and Astronomy, University of Nottingham, Nottingham, Select, United Kingdom; 2SPMMRC, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom

CEST is increasingly used to study a wide range of endogenous and exogenous species. However different species of interest overlap in the z-spectra even at high field due to line broadening caused by exchange. Here we propose a new combination of acquisition and analysis approaches to separate fast and slow exchanging species. Simulation and experimentation of a z-spectra database for two pools exchanging at different rates is presented here, and was used successfully in fitting pool protons overlapping on the z-spectra, both numerically and empirically.