Tian Liu1, 2, Andrew D. Schweitzer1, Karen S. Zheng1, Stephen Seedial1, Alexander Shtilbans3, Dale J. Lange3, Yi Wang1, Apostolos John Tsirouis1
1Radiology, Weill Cornell Medical College, New York, United States; 2MedImageMetric LLC, New York, United States; 3Hospital for Special Surgery, New York, United States
Amyotrophic lateral sclerosis (ALS) is an devastating disease yet there is currently no quantitative laboratory, imaging, or electrophysiological test that correlates with disease severity. In this study, we applied quantitative susceptibility mapping to ALS patients, and compared their susceptibility values in motor cortex to control subjects without ALS. Statistically significant increase in susceptibility was found in ALS patients, suggesting that QSM has the potential to be the first quantitative imaging biomarker for patients with ALS.