Abstract #2857

Assessing Regional Gray and White Matter Changes to Understand the CNS Related Symptoms of Myotonic Distrophy Type-1

Marco Bozzali¹, Laura Serra², Barbara Span², Mario Torso², L Lispi³, A Rosini³, S. Costanzi-Porrino³, M. Giacanelli³, Carlo Caltagirone⁴, A Petrucci³

¹Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy; ²Neuroimaging Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy; ³Neurology and neurophysiopathology Unit, "San Camillo Forlanini" Hospital, Rome, Italy; ⁴Neurological and behavioural Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy

This voxel-based morphometry study investigates associations between regional grey (GM) and white matter (WM) volumes in patients with genetically confirmed Steinert disease (SD). Interesting associations between GM and WM atrophy, and clinical and neuropsychological features were found, which contribute to clarify some pathophysiological aspects of CNS involvement in SD.