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Abstract #2857

Assessing Regional Gray and White Matter Changes to Understand the CNS Related Symptoms of Myotonic Distrophy Type-1

Marco Bozzali1, Laura Serra2, Barbara Span2, Mario Torso2, L Lispi3, A Rosini3, S. Costanzi-Porrino3, M. Giacanelli3, Carlo Caltagirone4, A Petrucci3

1Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy; 2Neuroimaging Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy; 3Neurology and neurophysiopathology Unit, "San Camillo Forlanini" Hospital, Rome, Italy; 4Neurological and behavioural Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy

This voxel-based morphometry study investigates associations between regional grey (GM) and white matter (WM) volumes in patients with genetically confirmed Steinert disease (SD). Interesting associations between GM and WM atrophy, and clinical and neuropsychological features were found, which contribute to clarify some pathophysiological aspects of CNS involvement in SD.