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Abstract #2865

CSF Biomarkers Associate with GM Volume and Brain Microstructural Changes Mainly from Default Mode Network in Alzheimers Disease

Xiaozhen Li1, Tie-Qiang Li2, Niels Andreasen3, Maria Kristoffersen Wiberg4, Eric Westman1, Lars-Olof Wahlund1

1NVS Department, Karolinska Institutet, Stockholm, Sweden; 2Department of Medical Physics, Karolinska Institutet, Stockholm, Sweden; 3Alzheimer Disease Research Center, Karolinska Institutet, Stockholm, Sweden; 4Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, Sweden

Alzheimers disease (AD) is the most common dementia in elderly people. The pathological hallmark of AD is amyloid plaques and neurofibrillary tangles, which are made up of Aβ42 and p-tau, respectively. Decreased levels of Aβ42 and increased levels of total tau protein (T-tau) and p-tau in CSF are useful and valid tool for the diagnosis and prognosis of AD. In this study, we investigated the correlation between AD CSF biomarkers and grey matter volume and brain microstructural changes using VBM analysis and DTI measurement.