Abstract #2866

A Preliminary Diffusional Kurtosis Imaging Study of Parkinson Disease: Comparison with Conventional Diffusion Tensor Imaging

Koji Kamagata¹, Masaaki Hori¹, Keigo Shimoji¹, Michimasa Suzuki¹, Atsushi Nakanishi¹, Hiroyuki Tomiyama², Yumiko Motoi², Issei Fukunaga³, Humitaka Kumagai¹, Nobutaka Hattori², Shigeki Aoki¹

¹Department of Radiology, Juntendo university, Tokyo, Japan; ²Department of Neurology, Juntendo university, Tokyo, Japan; ³Department of Radiology, Juntendo University, Tokyo, Japan

White matter abnormalities have been extensively investigated in Parkinson disease (PD). Diffusion tensor imaging (DTI) studies have reported diffusion abnormalities in the cerebral white matter in patients with PD, but these findings are controversial. The aims of this preliminary study were to investigate how the white matter is altered in PD as measured with DKI and to compare this to what is shown with DTI. DKI can detect changes in the cerebral white matter of PD patients more sensitively than conventional DTI. DKI may enable improved monitoring of disease progression and more effective treatment planning.