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Abstract #2866

A Preliminary Diffusional Kurtosis Imaging Study of Parkinson Disease: Comparison with Conventional Diffusion Tensor Imaging

Koji Kamagata1, Masaaki Hori1, Keigo Shimoji1, Michimasa Suzuki1, Atsushi Nakanishi1, Hiroyuki Tomiyama2, Yumiko Motoi2, Issei Fukunaga3, Humitaka Kumagai1, Nobutaka Hattori2, Shigeki Aoki1

1Department of Radiology, Juntendo university, Tokyo, Japan; 2Department of Neurology, Juntendo university, Tokyo, Japan; 3Department of Radiology, Juntendo University, Tokyo, Japan

White matter abnormalities have been extensively investigated in Parkinson disease (PD). Diffusion tensor imaging (DTI) studies have reported diffusion abnormalities in the cerebral white matter in patients with PD, but these findings are controversial. The aims of this preliminary study were to investigate how the white matter is altered in PD as measured with DKI and to compare this to what is shown with DTI. DKI can detect changes in the cerebral white matter of PD patients more sensitively than conventional DTI. DKI may enable improved monitoring of disease progression and more effective treatment planning.