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Abstract #2867

Test-Retest Reliability of Brain Volume Measurements

Julian R. Maclaren1, Zhaoying Han1, Sjoerd B. Vos1, 2, Christoph Seeger1, 3, Alexander Brost1, Nancy J. Fischbein1, Roland Bammer1

1Center for Quantitative Neuroimaging, Dept. of Radiology, Stanford University, Stanford, CA, United States; 2Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands; 3Pattern Recognition Lab, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany

The monitoring of neurodegenerative disease progression may be assisted by quantitative measurement of the volume of structures in the human brain. We performed 120 scans on 3 volunteers over a period of 31 days. The resulting dataset is available online and is a valuable resource for quantifying the repeatability of brain volume measurements. Results show that lateral ventricle volume, in particular, varies significantly from day to day. This could potentially mask the effects of disease and should be taken into consideration in any analysis performed using ventricle volume.