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Abstract #2876

Voxel-Based Analysis of Cerebral Perfusion Changes in Alzheimer Disease and Mild Cognitive Impairment Measured with a Novel 3D Arterial Spin Labeling Technique

Yong Zhang1, He Wang1, Guang Cao1, Qing Mao1, Bei Ding2, Hua-Wei Ling2

1GE Healthcare, Shanghai, China; 2Ruijin Hospital, Shanghai, China

This preliminary study investigated cerebral perfusion changes in Alzheimers disease (AD) and mild cognitive impairment (MCI) measured with a novel 3D arterial spin labeling technique to facilitate more accurate voxel-wise comparison. Twenty-four AD patients, seventeen MCI patients and twenty-one healthy controls were recruited. In addition to the decreased CBF regions in the bilateral temporo-parieto-occipital cortex, increased CBF was observed in bilateral thalamus, right temporal lobe and paracentral lobule for AD patients and in bilateral frontal lobes and right temporal lobe for MCI patients. Our results suggested the existence of the different patterns of hyperperfusion along with the disease evolvement.