Abstract #2877

An Integrated Resting-State fMRI and DTI Based Connectivity Analysis to Understand Brain Alteration Affected by Alzheimers Disease and Amnestic Mild Cognitive Impairment

Shantanu Majumdar¹, David C. Zhu¹,²

¹Department of Radiology, Michigan State University, East Lansing, MI, United States; ²Department of Psychology, Michigan State University, East Lansing, MI, United States

Integration of resting-state functional connectivity analysis with the DTI based white matter connectivity analysis can provide overall neuronal connectivity information about the regions of interest involved. In Alzheimers disease (AD) and amestic mild cognitive impairment patients, certain specific brain regions are affected at early stages than other regions. In this work, we present a quantitative analysis of combined functional-structural connectivity to study the changes in certain cortical regions of the brain known to be affected in AD.