Zhaoying Han1, Julian R. Maclaren1, Alexander Brost1, Sjoerd B. Vos1, 2, Christoph Seeger1, 3, Nancy J. Fischbein1, Roland Bammer1
1Center for Quantitative Neuroimaging, Department of Radiology, Stanford University, Palo Alto, CA, United States; 2 Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands; 3Pattern Recognition Lab, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany
Biomarkers for neurodegenerative diseases derived from MRI brain structures are promising to translate into clinical practice by comparing a patients brain to those in a database. The aim of this study was to choose the well-defined standard protocol from the ADNI project and compare it to the standard GE BRAVO sequence used in clinical routine at our institution and assess comparability of volumetric measurements. Statistical analysis shows that ADNI and our clinical BRAVO protocol although tightly matched in terms of scan parameters have statistically significant differences in estimated volumes of the lateral ventricles and hippocampus with Freesurfer segmentations.