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Abstract #2881

Age-Related Changes in Regional Brain T1 and T2 Relaxation Times in the Healthy Mouse at 17.6 T

Firat Kara1, Fu Chen1, Itamar Ronen2, Huub J. M. de Groot1, Jorg Matysik1, 3, A Alia1, 2

1Leiden Institute of Chemistry, Leiden University, Leiden, Netherlands; 2Department of Radiology, Leiden University Medical Center, Leiden, Netherlands; 3Institut fuer Analytische Chemie, Universitaet Leipzig, Leipzig, Germany

The estimates of in vivo T2 and T1 at 17.6 T will be useful to optimize pulse sequences for optimal image contrast and will serve as baseline values against which disease-related relaxation changes can be assessed in mice. This study establishes for the first time the normative T2 and T1 values at 17.6 T over different mouse brain regions with age. T2 values at 17.6 T typically increased with age in multiple brain regions except in the hypothalamus and the caudate-putamen, where a slight decrease was observed. Furthermore, T1 values in various brain regions of young and old mice are presented at 17.6 T.