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Abstract #2882

2D L-COSY MR Spectroscopy Detects Changes in Brain Glucose Level in a Mouse Model of Alzheimer's Disease

A Alia1, 2, Firat Kara1, Niels Braakman1, Mark A. van Buchem2, Reinhard Schliebs3

1Leiden Institute of Chemistry, Leiden University, Leiden, Netherlands; 2Department of Radiology, Leiden University Medical Center, Leiden, Netherlands; 3University of Leipzig, Leipzig, Germany

Alzheimers disease (AD) is the most common neurodegerative disease afflicting mainly the elderly. Glucose metabolism and uptake has been shown to be impaired during AD which is proposed to be an important cause of neurodegeneration. However the cause of impairment of glucose uptake/metabolism in AD brain and its correlation with plaque deposition is not clear. The aim of this study is to investigate regional brain glucose levels changes with age using two dimensional correlated MR spectroscopy (L-COSY) at 9.4 T. Our results indicate that age dependent decline in glucose level occur primarily in plaque affected areas of TG2576 mice.