Wendy W. Ni1, 2, Thomas Christen1, Greg Zaharchuk1
1Department of Radiology, Stanford University, Stanford, CA, United States; 2Department of Electrical Engineering, Stanford University, Stanford, CA, United States
In this study, we demonstrate the feasibility of a novel myelin water fraction (MWF) measurement method that utilizes free induction decay (FID) and post-spin echo refocused gradient echoes acquired with the Gradient-Echo Sampling of FID and Echo (GESFIDE) sequence. Preliminary results are mostly consistent with literature values of MWF in several regions of interest. While the method needs further improvement of the signal model and optimization of imaging parameters, it demonstrates great potential for examining myelination state in the human brain.