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Abstract #2902

Myelin Water Fraction Measurement Using Free Induction Decay and Refocused Gradient Echoes

Wendy W. Ni1, 2, Thomas Christen1, Greg Zaharchuk1

1Department of Radiology, Stanford University, Stanford, CA, United States; 2Department of Electrical Engineering, Stanford University, Stanford, CA, United States

In this study, we demonstrate the feasibility of a novel myelin water fraction (MWF) measurement method that utilizes free induction decay (FID) and post-spin echo refocused gradient echoes acquired with the Gradient-Echo Sampling of FID and Echo (GESFIDE) sequence. Preliminary results are mostly consistent with literature values of MWF in several regions of interest. While the method needs further improvement of the signal model and optimization of imaging parameters, it demonstrates great potential for examining myelination state in the human brain.