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Abstract #2910

Cine 2D Phase-Contrast MRI Free of Blood Flow Artifacts to Study Cervical Cerebrospinal Fluid Flow.

Malek I. Makki1, Cyrile Cappel2, Bader Chaarani2, Catherine Gondry-Jouet3, Olivier Baledent4

1MRI Research, University Children Hospital, Zurich, Switzerland; 2BioFlowImage, University Hospital Picardie Jules Verne, Amiens, France; 3Radiology, University Hospital Picardie Jules Verne, Amiens, France; 4BioFlowImage, University Hospital Picardie Jules Verne , Amiens, France

The major source of errors affecting the assessment of cerebro-spinal fluid (CSF) dynamic with 2D cine phase-contrast MRI (cine-PC) in the aqueduct of Sylvius and the subarachnoid space are artifacts from blood leakage and inappropriate velocity encoding value. These make it difficult for an early and accurate diagnosis of impaired CSF flow and bias the quantification of velocity and volume leading to poor predictive outcome of surgical intervention. This investigation aims to develop a new 2D cine-PC sequence to assess CSF flow free of such artifacts and sensitive to slow CSF flow.