Abstract #2911

Effect of APOE4 on Partial Volume-Corrected Diffusion Anisotropy in Patients with AD and MCI&[reg]&[Prime]

Kyung Mi Lee¹, Min-Ji Kim², Chang Woo Ryu², Ji Seon Park¹, Hak Young Rhee³, Eui Jong Kim¹, Geon-Ho Jahng²

¹Radiology, Kyung Hee University Hospital, Kyung Hee University, Seoul, Korea; ²Radiology, Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul, Korea; ³Neurology, Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul, Korea

To prospectively evaluate whether Apolipoprotein E4 (APOE4) carriers were altered in brain diffusion anisotropy compared with noncarriers in Alzheimer disease (AD), mild cognitive impairment (MCI) and cognitively normal (CN) subjects, 25 AD, 25 MCI, and 25 CN subjects were scanned DTI data. Furthermore, we applied a partial volume correction (PVC) method to minimize contributions of cerebrospinal fluid on FA and trace maps. We concluded that regional microstructural changes of brain in APOE4 carriers of AD and MCI subjects were found and application of the PVC should be helpful for accurate evaluation of microstructural changes in cognitive decline patients.