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Abstract #2947

Altered Metabolism in the Developing Auditory Cortex of Chicks Exposed to Chronic High Decibel Noise: A Proton NMR-Based Metabonomic Study

Vivek Kumar1, Pawan Kumar2, Uma Sharma2, T C. Nag1, Naranamangalam R. Jagannathan2, Shashi Wadhwa1

1Department of Anatomy, All India Institute of Medical Sciences, New Delhi, Delhi, India; 2Department of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, Delhi, India

Proper functional development of the auditory cortex and its synaptic connections require balance between excitatory and inhibitory neurotransmission, which is affected by the acoustic stimulation. Our proton NMR data showed that chronic noise exposure significantly decreases GABA level and increases the glutamate level. This NMR based metabonomic study revealed that chronic exposure of high decibel sound (110dB) significantly alters this balance in the developing auditory cortex. Further, results indicated that the sound characteristic [patterned (music) and un-patterned (noise)] has a profound effect on this balance. High sound pressure level also significantly affects the energy metabolism of the developing auditory cortex.