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Abstract #2946

Unilateral Hearing Loss in Children Affects Development of the Default Mode Network

Vincent J. Schmithorst1, 2, Scott Holland2, Elena Plante3

1Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States; 2Radiology, Children's Hospital Medical Center, Cincinnati, OH, United States; 3Speech, Language, and Hearing Sciences, University of Arizona - Tucson, Tucson, AZ, United States

Little is currently known about how subtle sensory deficits may affect the development of higher-order cognitive processing. Children with unilateral hearing loss (UHL) exhibit deficits in sound localization, as the additional information from binaural input is unavailable. We investigated the neural correlates of audio-visual association in children with UHL as compared with normal-hearing controls. While minimal differences in activation patterns were seen, children with UHL displayed reduced deactivation in anterior and posterior default-mode network (DMN) regions. This neurobiological deficit, also seen in ADHD and math disability, may underlie the academic and behavioral deficits seen in children with UHL.