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Abstract #2945

Small-World Brain Networks in Resting State in Typically Developing Children and Adolescents

Minjie Wu1, Alexander Kmicikewycz1, Donatello Arienzo1, Lisa Lu1, 2, Shaolin Yang1, Mani Pavuluri1

1Psychiatry, University of Illinois at Chicago, Chicago, IL, United States; 2Psychology, Roosevelt University , Chicago, IL, United States

Combining rs-fcMRI and graph theory analyses, this study aims to quantitatively characterize the organizational change of functional brain networks in normal development during childhood and adolescence. No significant correlation was found between age and global network metrices (small-worldness or global efficiency). Significant age-related changes were found in local efficiency and degree at node level at right lingual gyrus, left medial orbitofrontal area, pericalcarine, anterior cingulate gyri. These age-related changes in node-level metrices but not global metrices may suggest topological fine tuning of resting state brain networks in children and adolescents.