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Abstract #2987

in vivo and ex vivo Multimodal Characterisation of Human Carotid Artery Atherosclerosis Plaques.

Mohamed Tachrount1, Fiona Kennedy1, David A. Doig1, Matthew Adams1, Tarek A. Yousry1, Xavier Golay2, David L. Thomas1, Rolf H. Jager1

1Department od brain repair and rehabilitation, UCL Institute of Neurology, London, United Kingdom; 2Department od brain repair and rehabilitation, University College London, London, United Kingdom

Plaque ulceration, thrombosis and intraplaque haemorrhage are the main causes of stroke and clinical symptoms of atherosclerosis. In addition to the degree of luminal narrowing, characterisation of the plaque composition and ultrastructure is important for the assessment of stroke risk. Ex vivo MRI at very high magnetic field allows for detailed assessment of the plaques components. In this multimodal study, ex vivo plaque contrast and relaxation characteristics were analysed based on high spatial resolution images and compared to in vivo MRI and CT images.