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Abstract #3056

Cerebral Blood Flow Measurement Obtained by PET/MR Dual-Modality Imaging System

Parinaz Massoumzadeh1, Yi Su1, Joshua S. Shimony1, Andrei Vlassenko1, Jonathan McConathy1, Tammie Benzinger1

1Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, United States

Cerebral blood flow (CBF) has been compared using PET and MR, methods but not using a PET/MR dual-modality imaging system. Here, we compare CBF measurement obtained using three methods: dynamic susceptibility contrast (DSC) MR, Dynamic F18-FDG, and O-15 water PET scans for patients with brain tumor. We use a PET/MR scanner (Siemens Biograph mMR). MR based CBF were found to be correlated with PET CBF at both voxel and regional level, although the correlation was lower than the correlations between [015]PET and FDG imaging. Further investigation is ongoing to investigate the difference between PET and MR based CBF measurements.