Cerebral Blood Flow Measurement Obtained by PET/MR Dual-Modality Imaging System

Parinaz Massoumzadeh¹, Yi Su¹, Joshua S. Shimony¹, Andrei Vlassenko¹, Jonathan McConathy¹, Tammie Benzinger¹

Cerebral blood flow (CBF) has been compared using PET and MR, methods but not using a PET/MR dual-modality imaging system. Here, we compare CBF measurement obtained using three methods: dynamic susceptibility contrast (DSC) MR, Dynamic F18-FDG, and O-15 water PET scans for patients with brain tumor. We use a PET/MR scanner (Siemens Biograph mMR). MR based CBF were found to be correlated with PET CBF at both voxel and regional level, although the correlation was lower than the correlations between [015]PET and FDG imaging. Further investigation is ongoing to investigate the difference between PET and MR based CBF measurements.