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Abstract #3057

Time to Peak Based Differentiation of Functional Placental Compartments in the Mouse Model

Fabian Kording1, Wedegaertner Ulrike1, Nils Daniel Forkert2, Jan Sedlacik1, Gerhard Adam1, Chressen K. Much1

1Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, Germany; 2Department of Computational Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, Germany

The assessment placental perfusion using dynamic contrast enhanced MRI is of increasing importance for early prediction of fetal growth restrictions and vascular complications during pregnancies. To assess differences in the placenta perfusion in experimental studies analysis is performed as an average over the whole placenta. However, the mouse placenta consists of two different functional zones and differentiating the two compartments may lead to additional important information. In this work placenta functional compartments were successfully differentiated using time-to-peak values of the contrast agent time curve. Perfusion analysis of both compartments revealed significant differences which could be beneficial for further studies.