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Abstract #3064

Automatic AIF Estimation in Multi-Echo DSC-MRI of Pediatric Patients - Avoiding the Noise Floor

Allen T. Newton1, 2, Jack T. Skinner1, Christopher C. Quarles1

1Radiology and Radiological Sciences, Vanderbilt University Institute of Imaging Science, Nashville, TN, United States; 2Radiology and Radiological Sciences, Monroe Carell Jr. Children's Hopsital at Vanderbilt, Nashville, TN, United States

We present a simple method by which investigators performing multi-echo DSC-MRI perfusion studies can identify voxels saturating into the noise floor at later echo times, and show the effect of removing these voxels from analysis on AIF estimation. Furthermore, our study evaluates these methods in a population of pediatric patients, demonstrating their applicability in an actual clinical context.