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Abstract #3069

DSC-MRI Simulations: What Is the Correct Model for the in vivo Tissue Residue Function?

Amit Mehndiratta1, Fernando Calamante2, Bradley J. MacIntosh3, David E. Crane3, Stephen J. Payne1, Michael A. Chappell1

1Institute of Biomedical Engineering, University of Oxford, Oxford, Oxfordshire, United Kingdom; 2Melbourne Brain Centre - Austin campus, Brain Research Institute, Heidelberg, Victoria, Australia; 3Medical Physics, University of Toronto, Toronto, ON, Canada

Exponential residue function is commonly used in DSC MRI simulations for cerebral haemodynamic approximation to validate novel deconvolution methodologies. However, the haemodynamics is significantly altered in pathology where exponential approximation might be no more valid. In the study in-vivo observed residue function with non-parametric CPI method were approximated with four commonly used analytical expressions where bi-exponential expression was found to be more realistic approximation of normal and pathological variation in haemodynamics.