Amit Mehndiratta1, Fernando Calamante2, Bradley J. MacIntosh3, David E. Crane3, Stephen J. Payne1, Michael A. Chappell1
1Institute of Biomedical Engineering, University of Oxford, Oxford, Oxfordshire, United Kingdom; 2Melbourne Brain Centre - Austin campus, Brain Research Institute, Heidelberg, Victoria, Australia; 3Medical Physics, University of Toronto, Toronto, ON, Canada
Bolus dispersion is a significant problem in perfusion imaging because of remote AIF measurement. It is challenging to accurately estimate CBF in presence of dispersion; in this study our motivation was to investigate the accuracy in CBF estimate with a number of deconvolution methods, and also investigate the possibility to separate the effects of dispersion from cerebral haemodynamics using these techniques. The ambiguity between true residue function and dispersion could not be resolved with any of the deconvolution methods, but accurate estimates of cerebral perfusion can be achieved with an effectively non-parametric CPI approach even in presence of dispersion.