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Abstract #3072

Susceptibility Induced Signal Quenching in DCE-MRI Is Tissue Dependent

Xin Li1, Seymur Gahramanov2, Charles S. Springer, Jr. 1, William D. Rooney1, Edward A. Neuwelt2

1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States; 2Department of Neurology, Oregon Health & Science University, Portland, OR, United States

Conventional gradient echo Dynamic-Contrast-Enhanced (DCE) MRI protocols acquire data at short but finite echo time (TE). During contrast reagent (CR) bolus passage, T2* related MRI signal reduction (mainly due to susceptibility gradient introduced by CR) may not be negligible even with short TE, especially at ultra-high field. Using a sequential multi-session DCE-MRI data collection at 11.75 T, we demonstrate that the T2* signal loss in DCE-MRI is tissue dependent and most pronounced for tissues with low CR extravasation which transiently experience large intra-voxel susceptibility gradients.