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Abstract #3083

On the Application of Anomalous Diffusion Metrics in Animal Stroke Models

Farida Grinberg1, Ezequiel Farrher1, Luisa Ciobanu2, Nadim Jon Shah1, 3

1Institute of Neuroscience and Medicine 4 - Medical Imaging Physics, Forschungszentrum Juelich, Juelich, Germany; 2Neurospin, CEA, Gif-sur-Yvette, France; 3Department of Neurology, Faculty of Medicine, JARA, RWTH Aachen University, Aachen, Germany

We analyse the sensitivity of the stretched- exponential model in providing contrast for ischemic lesions in animal stroke models. Good fits in the extended range of the diffusion weightings were obtained. In frame of the proposed analytical models, the stretched-exponential function is indicative of anomalous diffusion mechanisms and provide complementary means to infer valuable microstructural information. We obtained promising results in terms of image contrast and better understanding of pathological changes in the ischemic lesions.