Xingju Nie1, Edward S. Hui1, Jens H. Jensen1, Joseph A. Helpern1, 2, Ann-Charlotte E. Granholm-Bentley2, Heather A. Boger2, Maria F. Falangola1, 2
1Radiology and Radiological Science, Center for Biomedical Imaging, Medical University of South Carolina, Charleston, SC, United States; 2Neurosciences, Medical University of South Carolina, Charleston, SC, United States
The goal of this study was to utilize a recently developed cerebral microenvironment modeling (CMM) method to investigate the morphological abnormalities in the prefrontal cortex of young Ts65Dn mice. CMM relates diffusional kurtosis imaging (DKI) data to specific biophysical tissue characteristics. We demonstrated that CMM parameters are sensitive indicators of changes in the complexity of the neurite architecture associated with abnormal brain development and maturation in this model.