Xiaojie Wang1, Matthew Cusick2, Robert S. Fujinami2, Sheng-Kwei Song3, 4
1Chemistry, Washington University, St. Louis, MO, United States; 2Pathology, University of Utah, Salt Lake City, UT, United States; 3Radiology, Washington University, St. Louis, MO, United States; 4Hope Center for Neurological Disorders, Washington University, St. Louis, MO, United States
SJL-EAE mice were treated with LDK or vehicle from the onset of first relapse to the study end-point (37 day post immunization). 99-direction DBSI was performed to examine the spinal cord white matter pathology. Axon and myelin integrity of the spinal cord white matter was assessed using axial and radial diffusivity, respectively, while inflammation extent was evaluated using cell ratio and edema water ratio derived by DBSI. LDK diminished the disease activity through the anti-inflammatory, axon preservation and probably remyelination effect.