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Abstract #3122

Quantitative BOLD Analysis Using a Numerical Model. Blood Volume, Oxygenation and Vessel Size Measurement in the Rat Brain.

Nicolas Pannetier1, 2, Benjamin Lemasson3, 4, Thomas Christen5, Greg Zaharchuck5, Emmanuel Luc Barbier3, 4, Norbert Schuff1, 2

1Department of Radiology, University of California San Francisco, San Francisco, CA, United States; 2Centre for Imaging of Neurodegenerative Diseases, Veteran Affairs Medical Centre, San Francisco, CA, United States; 3Grenoble Institute of Neurosciences, Grenoble University, La Tronche, Rhone-Alpes, France; 4U836, INSERM, La Tronche, Rhone-Alpes, France; 5Department of Radiology, Stanford University, Stanford, CA, United States

The analytical description of the susceptibility-related MR dephasing is used to assess the microvasculature. However, analytical solutions are discordant with Monte Carlo simulations and this discrepancy lead to bias vascular estimates. Moreover recent results demonstrate that BVf and SO2 cannot be assessed at once in qBOLD. In this work, we proposed a new integrative approach to simultaneously assess blood volume, oxygenation and the radius of the vessel. We built up a densely sampled lookup table by simulating the MR signal provided by a Gradient Echo Sampling of the FID and SE sequence prior and post injection of a contrast agent. We acquired the corresponding sequence on rats with focal brain ischemia and we estimated the vascular parameters from the LT.