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Abstract #3123

Does T2' Depend on the Measurement Method? Considerations for Quantitative BOLD Oxygenation

Wendy W. Ni1, 2, Thomas Christen1, Zungho Zun1, Greg Zaharchuk1

1Department of Radiology, Stanford University, Stanford, CA, United States; 2Department of Electrical Engineering, Stanford University, Stanford, CA, United States

In this study, we compare the measurement of reversible contribution R2'=1/T2' of the transverse relaxation rate using nine methods characterized by three approaches: asymmetric spin echo (ASE), Gradient-Echo Sampling of FID and Echo (GESFIDE), and combined (COMBO). We found that the mean value, spatial SNR and inter-subject variation of resulting R2' maps differed significantly between methods, highlighting the importance of making a careful choice in R2' measurement method for quantitative BOLD (qBOLD) oxygenation measurements.