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Abstract #3124

Complex Patterns of Non-Gaussian Diffusion in Artificial Anisotropic Tissue Models

Farida Grinberg1, Ezequiel Farrher2, Ivan I. Maximov2, Nadim Jon Shah2, 3

1Institute of Neuroscience and Medicine , Forschungszentrum Juelich, Juelich, Germany; 2Institute of Neuroscience and Medicine, Forschungszentrum Juelich, Juelich, Germany; 3Faculty of Medicine, JARA, RWTH Aachen University, Aachen, Germany

We report on the results of the application of several non-Gaussian (diffusion kurtosis, log-normal distribution function, stretched exponential function) and anomalous diffusion models to describe experimental data in the anisotropic fibre phantoms. We focus on the influence of fibre packing density on the quantitative metrics of these models and compare their sensitivity to this parameter. We examine the power-law dependences of the apparent diffusivity on time and fibre density in the frame of anomalous diffusion model.