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Abstract #3134

Investigation of Diffusion Kurtosis Imaging of the Organ with Plenty of Perfusion/flow Effect

Yuriko Suzuki1, Marc Van Cauteren2

1Philips Electronics Japan, Minato-ku, Tokyo, Japan; 2Philips Healthcare Asia Pacific, Minato-ku, Tokyo, Japan

Diffusion Kurtosis Imaging (DKI) is a method to study the deviation of water diffusion from Gaussian distribution, which has been successfully applied to several brain diseases recently. However, in the organ with plenty of flow, DKI curve fitting is ruined. The aim of study is to define the DKI model which consider perfusion/flow component, and using this model, investigate how the conventional DKI fitting is affected by perfusion/flow. Our study has shown that large perfusion/flow fraction induced lower R2 of fitting, overestimated D and large error of estimated K.