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Abstract #3135

Does the Signal Arising from a Single Fascicle Significantly Deviates from a Monoexponential Decay with a Clinical Scanner?

Benoit Scherrer1, Maxime Taquet1, 2, Onur Afacan1, Simon K. Warfield1

1Computational Radiology Laboratory, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States; 2ICTEAM Institute, Universit catholique de Louvain, Louvain-la-Neuve, Belgium

Multiple works have shown that the diffusion attenuation in a voxel significantly deviates from a monoexponential decay. However, when imaging with a clinical scanner with long δ, it is not clear that the signal arising from a single fascicle is non-monoexponential. We hypothesize that the non-monoexponential behavior observed in voxels may reflect predominantly the presence of multiple fascicles with heterogeneous orientation and the presence of an additional compartment that is macroscopically isotropic. We imaged a region containing a single fascicle orientation, the body of the corpus and investigated the residual diffusion decay after subtracting the contribution of unrestricted diffusion.