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Abstract #3136

Microstructural Information by Double-Pulsed-Field-Gradient NMR: from Model Systems to Nerves

Darya Morozov1, Leah Bar2, Nir Sochen2, Yoram Cohen1

1School of Chemistry, Tel Aviv University, Tel Aviv, Israel; 2School of Mathematical Sciences, Tel Aviv University, Tel Aviv, Israel

Diffusion NMR is a powerful tool for gleaning microstructural information on opaque systems. We demonstrate that our modeling of d-PFG MR experiments, performed on a series of phantoms of increasing complexity where the ground truth is known a priori, can, without assuming the number of compartments, identify the number of restricted compartments, detect their sizes and determine their relative populations. In addition the model can identify free diffusion when presents in addition to the restricted compartments. This model was then used to study diffusion in excised nerves, showing that it provides a mean to obtain detailed microstructural information in nerves.