Peter F. Neher1,
Bram Stieltjes2, Ivo Wolf3, Hans-Peter Meinzer1,
Klaus Hermann Fritzsche1, 2
1Medical
and Biological Informatics, German Cancer Research Center (DKFZ), Heidelberg,
Germany; 2Quantitative Image-based Disease Characterization,
German Cancer Research Center (DKFZ), Heidelberg, Germany; 3Medical
Informatics, Mannheim University, Mannheim, Germany
Evaluation of diffusion MRI-based tractography methods is challenging and existing approaches for quantitative assessment mainly focus on measures of general tract overlap or the presence of anatomically plausible connections between brain regions. We present an evaluation of the local fiber direction plausibility on a voxel-wise basis. We further propose a reference-based validation procedure that aims at evaluating tractograms obtained from data of clinical quality using high quality HARDI data as a reference.