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Abstract #3334

Quantitative Susceptibility Mapping (QSM) for High Resolution Quantitative Cerebral Metabolic Rate of Oxygen (CMRO2)

Jingwei Zhang1, Mengchao Pei1, Tian Liu1, 2, Ajay Gupta1, Cynthia Wisnieff1, Pina C. Sanelli, 1, Pascal Spincemaille1, Yi Wang1

1Department of Radiology, Weill Medical College of Cornell University, New York, NY, United States; 2MedImageMetric LLC, New York, NY, United States

Accurate measurement of cerebral metabolic rate of oxygen (CMRO2) is highly desired for the assessment of brain cell function in health and in stroke.MRI offers the potential to map CMRO2 by estimating paragmagnetic deoxyhemoglobin concentration ([dHb]) from detected signal, which requires MRI signal modeling. We propose to use a rigorous deconvolution technique called quantitative susceptibility mapping (QSM) to map [dHb] and hence CMRO2.