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Abstract #3335

Measuring Changes in Brain Oxygenation Using Dynamic T1 Weighted Imaging

Bryan Haddock1, Henrik B.W. Larsson1, Adam E. Hansen1, Egill Rostrup1, 2

1Department of Diagnostics, Glostrup Hospital, Glostrup, Denmark; 2Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

We evaluated changes in intra- and extravascular brain oxygenation during oxygen challenge on 11 subjects with a new MRI technique (TOLD). A model is presented to quantify extravascular changes in oxygen tension from the TOLD signal. We Found an increase in extravascular tissue oxygenation for white and grey matter. Our Model calculates a change in oxygen tension close to literature values from data. TOLD and BOLD data sets for the same breathing challenge are compared revealing intravascular changes in oxygen tension is more rapid than extravascular responses.