Helen Erica D'Arceuil1,
Alexandre Coimbra2, Pamela Triano3, Margaret Dougherty3,
Julie Mello3, Michael E. Moseley4, Gary H. Glover,
Maarten Lansberg5, Francis Blankenberg6
1Diagnostic
Radiology, Stanford, Stanford, CA, United States; 2Genentech Inc,
South San Francisco, CA, United States; 3Department of
Rehabilitation Services, Stanford Hospital and Clinics, Stanford, CA, United
States; 4Diagnostic Radiology, Stanford University, Stanford, CA,
United States; 5Neurology and Neurological Sciences, Stanford
Stroke Center, Stanford Hospital and Clinics, Stanford, CA, United States; 6Pediatric
Radiology, Stanford Hospital and Clinics, Palo Alto, CA, United States
Enhanced task-based fMRI signals in primate and human brains, compared to the BOLD effect, have been realized using Ferumoxytol. We explored the use of ferumoxytol as a susceptibility contrast agent for CBV weighted resting state fMRI in 6 volunteers at 3T. While the amplitude of low frequency fluctuations was greater post ferumoxytol, the mean z-score and volume of visual and default mode networks were similar for BOLD and CBV weighted scans. CBV-RS-fMRI is robust and may be suitable for use in neurologically impaired or head trauma patients where regional tissue loss renders task FMRI problematic or even untenable.
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