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Abstract #3358

Ferumoxytol Enhanced Resting State fMRI and Relative Cerebral Blood Volume, RCBV, Mapping in Normal Human Brain

Helen Erica D'Arceuil1, Alexandre Coimbra2, Pamela Triano3, Margaret Dougherty3, Julie Mello3, Michael E. Moseley4, Gary H. Glover, Maarten Lansberg5, Francis Blankenberg6

1Diagnostic Radiology, Stanford, Stanford, CA, United States; 2Genentech Inc, South San Francisco, CA, United States; 3Department of Rehabilitation Services, Stanford Hospital and Clinics, Stanford, CA, United States; 4Diagnostic Radiology, Stanford University, Stanford, CA, United States; 5Neurology and Neurological Sciences, Stanford Stroke Center, Stanford Hospital and Clinics, Stanford, CA, United States; 6Pediatric Radiology, Stanford Hospital and Clinics, Palo Alto, CA, United States

Enhanced task-based fMRI signals in primate and human brains, compared to the BOLD effect, have been realized using Ferumoxytol. We explored the use of ferumoxytol as a susceptibility contrast agent for CBV weighted resting state fMRI in 6 volunteers at 3T. While the amplitude of low frequency fluctuations was greater post ferumoxytol, the mean z-score and volume of visual and default mode networks were similar for BOLD and CBV weighted scans. CBV-RS-fMRI is robust and may be suitable for use in neurologically impaired or head trauma patients where regional tissue loss renders task FMRI problematic or even untenable.