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Abstract #3364

Association of Lesion and Background Parenchyma in Diagnostically Challenging Breast Lesions

Ana Paula Klautau Leite1, 2, Melanie Freed1, Melanie Moccaldi3, Kai Tobias Block4, Amy Melsaether3, Alana Amarosa3, Sungheon Kim1, Linda Moy3

1Radiology, Center for Biomedical Imaging, New York Universiy School of Medicine, New York, United States; 2Radiology, Hospital das Clinicas- FMUSP, School of Medicine - University of Sao Paulo, Sao Paulo, SP, Brazil; 3Radiology, Cancer Institute, New York University School of Medicine, New York, United States; 4Radiology, NYU Langone Medical Center, New York, United States

The relationship between a lesion in the breast and its effect on contrast uptake kinetics in the breast parenchyma (PS) is unclear. This study investigated whether the quantitative analysis of MR contrast-enhancement kinetics of BP and lesions improves our ability to discriminate between benign and malignant tumors. We analyzed 102 lesions using a linear principal component analysis (PCA) and found that we can correctly identify benign lesions compared to malignant lesions by quantitatively comparing its enhancement with the adjacent BP. We almost reached statistical significance when performing the same analysis on malignant lesions.