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Abstract #3365

Age Correlation of Background Breast Tissue Enhancement Measured from the Entire Segmented Fibroglandular Tissue and the Hot-Spot in DCE-MRI

Xiaoyong Wang1, Jeon-Hor Chen2, Christine Hsu2, Shadfar Bahri1, Hon J. Yu1, Peter T. Fwu1, Muqing Lin1, Min-Ying Su1

1Center for Functional Onco-Imaging, University of California, Irvine, CA, United States; 2Center for Functional Onco-Imaging, University of California Irvine, Irvine, CA, United States

This work analyzed the background breast tissue enhancement in the contralateral normal breast of patients diagnosed with breast cancer. A computer program is used to segment the entire fibroglandular tissue, and a kernel of 3 by 3 pixels is used to search the hot spot. The hotspot enhancement is 2 fold higher compared to the mean background tissue enhancement. A negative correlation with age was found (r=0.35 for hotspot, r=0.33 for mean tissue enhancement). The presented method may be used to evaluate the role of background tissue enhancement as a risk factor in development of contralateral breast cancer.