Abstract #3382

Association of Apparent Diffusion Coefficient with Molecular Biomarkers (ER, PR, HER2 Status) in Invasive Breast Cancer Patients Using Diffusion Weighted MR Imaging

Naranamangalam R. Jagannathan¹, Rani G. Sah¹, Uma Sharma¹, Rajinder Parshad², Vurthaluru Seenu², Sandeep Mathur³

¹Department of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, Delhi, India; ²Department of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, Delhi, India; ³Department of Pathology, All India Institute of Medical Sciences, New Delhi, Delhi, India

Apparent diffusion coefficient (ADC) was calculated using diffusion weighted imaging in 72 invasive ductal carcinoma patients at 1.5T with known HER2, ER and PR status. Mean ADC in HER2+, ER+ and PR + were not significantly different compared to HER2-, ER- and PR- patients. Age of ER+ (4911.3years) patients was statistically significant compared to ER- (4311.3years). Measured ADC was not significant but showed variation (0.7-1.4x10-3 mm2/s) with the different tumor sub types which might be attributed to intratumor and intertumor heterogeneous nature of breast lesions or other molecular features of breast cancer which is influenced by genomic variation, etc,.