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Abstract #3413

Microbeam Radiation Therapy Effects on White Matter Assessed by Fiber Tractography

Yohan van de Looij1, 2, Audrey Bouchet3, 4, Benoit Pouyatos3, Luc Renaud5, Elke Bruer-Krisch4, Graldine Le Duc4, Jean A. Laissue6, Raphal Serduc3

1Division of Child Growth & Development, University of Geneva, Geneva, Switzerland; 2Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; 3Grenoble Institut des Neurosciences UMR836, Universit Joseph Fourier, Grenoble, France; 4European Synchrotron Radiation Facility, Grenoble, France; 5Centre de Recherche Cerveau et Cognition, Universit de Toulouse, Toulouse, France; 6Institute of Pathology, University of Bern, Bern, Switzerland

Microbeam Radiation Therapy (MRT) is a preclinical form of radiosurgery dedicated to brain tumor treatment. It uses micrometer-wide synchrotron-generated X-ray beams on the basis of spatial beam fractionation. Rat brain external capsule was damaged using MRT at different radiation deposition doses and assessed by DTI and fiber tractography. This study shows the excellent ability of DTI to classify the degree of injury of diverse lesions by DTI derived parameters and 3D representation of the WM fibers in the injury. The severity of the damage matches very well with DTI and FT results.